Lung Cancer Cell Lines As Tools For Biomedical Discovery And Research

Lung cancer cell lines have made a substantial contribution to lung cancer translational research and biomedical discovery.

Lung cancer cell lines as tools for biomedical discovery and research.

Although human lung tumor derived cell lines play an important role in the investigation of lung cancer biology and genetics there is no comprehensive study comparing the genotypic and phenotypic properties of lung cancer cell lines with those of the individual tumors from which they were derived. A systematic approach to initiating and characterizing cell lines from small cell and non small cell lung carcinomas has led to the current collection of more than 200 lung cancer cell lines a number that exceeds those for other common epithelial cancers combined. Lung cancer cell lines are crucial for translational and biomedical research. Human cancer cell lines are widely used in vitro models for studying cancer and its biology apart from being valuable tools for identifying biomarkers and genetic variants that impact drug sensitivities 2 3 cancer cell lines play a pivotal role in the early stages of drug discovery facilitating the screening of hundreds of potential drugs and their combinations before.

Lung cancer cell lines have made a substantial contribution to lung cancer translational research and biomedical discovery. Lung cancer cells were successfully cultured approximately 25 years after the establishment of a human cervical. High throughput technologies used in modern biomedical research generate large complex datasets that provide comprehensive information about patients animal models or cell lines being studied. While most cases arise in smokers lung cancer in lifetime never smokers is a major problem and for reasons we have reviewed may be considered a distinct entity lung cancers represent several histologic types and they may be divided into those arising from the central mainly small cell sclc or.

Lung cancer cell lines have made a substantial contribution to lung cancer translational research and biomedical discovery. We compared a variety of properties of 12 human non small cell lung carcinoma nsclc cell lines. A systematic approach to initiating and characterizing cell lines from small cell and non small cell lung carcinomas has led to the current collection of more than 200 lung cancer cell lines a number that exceeds those. Lung cancer cell lines as tools for biomedical discovery and research.